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Direct Synthesis of Segmented Glycolide Copolymers and Crystalline Materials Therefrom 6,498,229 (2002)
| The present invention is directed to a method for the direct, one-step synthesis of crystalline segmented glycolide copolymers having less than 80 percent glycolide-based sequences in the copolyester chain. The copolyester chain can also be formed using a polyether glycol as the initiator for the ring-opening copolymer... read more--> |
Absorbable and e-caprolactone (.EPSILON.-caprolactone) Polymers and Medical Devices 6,485,749 (2002)
| Crystalline, low melting .epsilon.-Caprolactone polymers which undergo accelerated hydrolysis, and their use as lubricant coatings and/or as coatings containing bioactive agents, as carriers of viable cells, and as coatings for open-cell micoporous template or constucts for tissue regeneration; the polymers bearing bas... read more--> |
Amorphous Polymeric Polyaxial Initiators and Compliant Crystalline Copolymers Therefrom 6,462,169 (2002)
| An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible co... read more--> |
Hydrogel-forming, Self-solvating Absorbable Polyester Copolymers, and Methods for Use Thereof 6,413,539 (2002)
| The present invention provides novel hydrogel-forming, self-solvating, absorbable polyester copolymers capable of selective, segmental association into compliant hydrogels upon contacting an aqueous environment. Methods of using the novel polyester copolymers of the invention in humans are also disclosed for providing... read more--> |
Phosphonylated Derivatives of Aliphatic Heterochain and Acrylate Polymers and Applications Thereof 6,395,259 (2002)
| A variety of phosphonylated heterochain polymers are disclosed, including, most preferably, phosphonylated polymethyl methacrylate. For each polymeric composition the phosphorous atom of a phosphorous-containing functional group is covalently bonded to a carbon atom of the polymeric chain. The phosphorous atoms are pre... read more--> |
High Strength Fibers of l-Lactide Copolymers, e-caprolactone (.EPSILON.-caprolactone), and Trimethylene Carbonate and Absorbable Medical Constructs Thereof 6,342,065 (2002)
| The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably .epsilon.-caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150.degree. C. and a crystallinity of at least 25%. Preferred are high mole... read more--> |
Polyester/Cyanoacrylate Tissue Adhesive Formulations 6,299,631 (2001)
| The present invention is directed to bioabsorbable adhesive/hemostatic formulations of a 2-alkoxyalkylcyanoacrylate and liquid or solid polymeric modifiers and adjuvant. The present adhesive formulations are useful as tissue adhesive/sealants, hemostatic agents, and as a means for patching or anastomic coupling of dama... read more--> |
Copolyesters with Minimized Hydrolytic Instability and Crystalline Absorbable Copolymers Thereof 6,255,408 (2001)
| The present invention is directed to crystalline, absorbable block/segmented copolymers which are the reaction product of a linear prepolymer which is a polyalkylene dicarboxylate of succinic, glutaric, sebacic or adipic acid and either glycolide, 1-lactide, or mixtures thereof. Preferably the prepolymer is preliminari... read more--> |
Peracylated Protein-based Sutures and Fabrics and Process For Making the Same 6,254,986 (2001)
| A method for modifying a protein or polypeptide is disclosed which includes the steps of dispersing a protein or polypeptide in an essentially non-aqueous medium and peracylating the protein or polypeptide with a cyclic anhydride having a carbon chain substituent selected from the group consisting of alkyl and alkenyl... read more--> |
Acylated Cyclodextrin Derivatives 6,204,256 (2001)
| A cyclodextrin derivative, wherein at least 60 percent of the free hydroxy groups of said cyclodextrin are acylated with acyl groups where at least one of said acyl groups comprise a free carboxylic group.... read more--> |
Absorbable e-caprolactone (.EPSILON.-caprolactone) Polymers And Medical Devices 6,197,320 (2001)
| Crystalline, low melting -Caprolactone polymers which undergo accelerated hydrolysis, and their use as lubricant coatings and/or as coatings containing bioactive agents, as carriers of viable cells, and as coatings for open-cell microporous template or constucts for tissue regeneration; the polymers bearing basic funct... read more--> |
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